Conventional Test Method:
Combination Tetanus and Diphtheria vaccines – separate serology tests for each vaccine
Alternative Test Method:
- Name & Description:
-
Tetanus and Diphtheria Serology test – single test for combination vaccine
For combination vaccines containing diphtheria and tetanus components, the serological assays listed in the PhEur under “2.7.6 Assay of Diphtheria, Method C” can be performed with the same group of animals used for the serological assay of the tetanus vaccine (adsorbed) when the common immunization conditions for the diphtheria and the tetanus components (e.g. doses, duration) have been demonstrated to be valid for the combined vaccine.
- Validation Status:
-
No information
- Regulatory Status:
-
EU: Accepted into PhEur
- Effect or Potential Effect on Animal Use:
-
Reduction
- References:
-
- Council of Europe (CE) (2008) 2.7.6 Assay of Diphtheria vaccine (adsorbed). In: European Pharmacopoeia, 6th ed. Strasbourg, France: CE.
- Information Last Reviewed:
- May 2012
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