|
One-Generation Reproduction Toxicity Study (OECD TG 415) AND
Two-Generation Reproduction Toxicity Study (OECD TG 416)
Developmental Neurotoxicity Study (OECD TG 426) AND
Prenatal Developmental Toxicity Study (OECD TG 414)
|
Extended One-Generation Reproduction Toxicity Study
Description and references |
No information |
OECD: TG 443 |
Reduction
(Use of fewer animals; more data collected from each animal) |
May 2012 |
Repeated Dose 28-day Oral Toxicity Study in Rodents
(OECD TG 407) AND Reproduction / Developmental Toxicity Screening Test
(OECD TG 421) |
Combined Repeated Dose Toxicity Study with the Reproduction/ Developmental Toxicity Screening Test
Description and references |
No information |
OECD: TG 422 (1996) |
Reduction |
May 2012 |
Prenatal Developmental Toxicity Study
(OECD TG 414) |
Embryonic Stem Cell Test (EST)
Description and references |
EU: Endorsed as valid by ECVAM for identifying non-, weakly and strongly embryotoxic chemicals
(2002) |
None |
Reduction
(For use as in vitro component of in vitro/in vivo reproductive toxicity testing strategy) |
May 2012 |
Micromass Embryotoxicity Assay
Description and references |
EU: Validated by ECVAM for identifying strong embryotoxic chemicals (2002) |
None |
Refinement
(Uses embryos from killed animals) |
May 2012 |
Whole Rat Embryo Embryotoxicity Assay
Description and references |
EU: Validated by ECVAM for identifying strong, weakly and non-embryotoxic chemicals (2000) |
No information |
Refinement
(Uses embryos from killed animals) |
May 2012 |
Frog Embryo Teratogenesis Assay- Xenopus (FETAX)
Description and references |
US: ICCVAM review concluded that FETAX was not sufficiently validated or optimized for regulatory purposes. Future activities were recommended (2000). |
None |
Replacement
OR
Reduction
|
May 2012 |
