Phototoxicity

Conventional
test method

Alternative Test Method

Last Reviewed
Name & Description Validation Status Regulatory Status Effect or Potential Effect on Animal Use
In vivo Mammalian Phototoxicity Test

In Vitro 3T3 Neural Red Uptake (NRU) Phototoxocity Test
Description and references

EU: Validated by EU/COLIPA and endorsed as valid by ESAC (1997)

OECD: TG 432 (2004)

EU: Accepted by European Commission as method B.41 in Annex V of EU Council Directive 67/548/EEC. This test must be used to determine phototoxic effects of chemicals, and animal tests are prohibited for this purpose in all EU member states (2000)

Replacement May 2012

 

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