Hematotoxicity

Conventional test method	Alternative Test Method				Last Reviewed
Conventional test method	Name & Description	Validation Status	Regulatory Status	Effect or Potential Effect on Animal Use	Last Reviewed
Haematotoxicity test for acute neutropenia (use of a second species)	Colony Forming Unit-Granulocyte/Macrophage (CFU-GM) Assay Description and references	EU: Validated by ECVAM (2006)	No information	Reduction (For use in place of a second species in the haematotoxicity test for acute neutropenia;, not a replacement as it relies on the availability of mouse Maximum Tolerated Dose data)	May 2012