Carcinogenicity

Conventional
test method

Alternative Test Method

 Last Reviewed
Name & Description Validation Status Regulatory Status Effect or Potential Effect on Animal Use
Long-Term (2 year) Rodent Carcinogenicity Bioassay
(OECD TG  451)
AND
Chronic Toxicity Studies
(OECD TG 452)		 Combined Chronic Toxicity/Carcinogenicity Study
Description and references		 No information OECD: TG 453 (2009) Reduction
(Additional test groups and lengths of exposure are required, perhaps limiting the reduction gains of combining protocols)		 May 2012
Long-Term (2 year) Rodent Carcinogenicity Bioassay
(OECD TG 451)		 Cell Transformation Assays
Description and references		 EU: ECVAM is currently conducting validation studies on SHE and Balb/3T3 cell transformation assays in collaboration with US and Japanese labs. OECD: Draft new test guidelines proposed for SHE assay and Balb/3T3 assay

EU: Method B.21

 Replacement

OR

Reduction
(if part of a tiered testing strategy that results in use of fewer animals)

 May 2012

 

• List of Abbreviations