Acute dermal irritation/corrosion (Draize rabbit skin irritation test)
(OECD TG 404) |
EPISKINTM
Description and references |
EU: Endorsed as valid by ECVAM for the prediction of both irritant and non-irritant substances (April 2007) |
OECD: TG 439 (2013)
EU: Test method B.46 in COM regulation 440/2008/EC (2008)
|
Replacement
OR
Reduction
(When part of a tiered testing strategy that results in use of fewer animals)
|
June 2014 |
EpiDermTM (SIT)
Description and references |
EU: Endorsed as valid by ECVAM for prediction of R38 skin irritating and no-label (non-skin irritating) test substances (2008) |
OECD: TG 439 (2010)
EU: Regulatory accepted as dermal percutaneous absorption test for the REACH program in place of in vivo animal studies (2008) |
Replacement
OR
Reduction
(When part of a tiered testing strategy that results in use of fewer animals)
|
May 2012 |
SkinEthicTM RHE (Reconstituted Human Epidermal) model
Description and references |
EU: Endorsed as valid by ECVAM for prediction of R38 skin irritating and no-label (non-skin irritating) test substances (2008) |
OECD: TG 439 (2010)
EU: Test method B.46 in COM regulation 440/2008/EC (2008)
|
Replacement
OR
Reduction
(When part of a tiered testing strategy that results in use of fewer animals)
|
May 2012 |
