Acute dermal irritation/corrosion
(In Vivo Rabbit Skin Corrosivity Test)
(OECD TG 404) |
Corrositex®
Description and references |
EU: Endorsed as valid by ECVAM for
testing acids, bases and their derivatives (2000)
US: Corrositex® endorsed as valid by ICCVAM as a stand-alone assay for evaluating the corrosivity or noncorrosivity of acids, bases, and acid derivatives. For other chemical and product classes Corrositex is valid for use as part of a tiered assessment strategy (1999)
|
OECD: TG 435 (2006)
US: Accepted as an alternative to a procedure specified in the U.S. Department of Transportation (DOT) Hazardous Materials Regulations (DOT-SP 10904) for DOT packing group classification of corrosive materials (1999)
|
Replacement
(for testing acids and bases)
OR
Reduction
(Other substances identified as corrosive will not progress to animal tests)
|
May 2012 |
Transcutaneous Electrical Resistance (TER) Test (In Vitro Skin Corrosion)
Description and references |
EU: Endorsed as valid by ECVAM for distinguishing between corrosive and non-corrosive chemicals (1998)
US: Endorsed as valid by ICCVAM to identify corrosive chemicals (substances identified as non-corrosive will require confirmation with animal-based tests) (2002)
|
OECD: TG 430 (2013)
EU: The European Scientific Committee for Cosmetic Products and Non-food products (SCCNFP) supports use of this method for the safety assessment of chemicals used as cosmetic ingredients. (1998); Accepted for corrosivity testing (Method B.40 in Annex of Commission Regulation 440/2008/EC) (2000, 2008)
|
Reduction
(skin from one
rat may be used to test up to five chemicals; in US substances identified as non-corrosive will require confirmation with animal-based tests)
Refinement
(Uses killed instead of live animal)
|
June 2014 |
Human Skin Model Test (EPISKINTM, EpiDermTM and SkinEthicTM)
Description and references |
EU: EPISKINTM, EpiDermTM and SkinEthicTM endorsed as valid by ECVAM (1998, 2000, 2006) US: EPISKINTM and EpiDermTM endorsed as valid by ICCVAM (2002) |
OECD: TG 431 (EPISKINTM and EpiDermTM 2004; SkinEthicTMincluded retroactively in 2006; revised in 2013))
EU: EPISKINTM and EpiDermTM accepted for corrosivity testing (Method B.40 bis. in Annex of Commission Regulation 440/2008/EC) (2000, 2008)
US: Accepted for corrosivity testing as part of the integrated testing strategy for corrosivity/irritation |
Replacement
(EU)
OR
Reduction (US)
(Substances identified as corrosive will not progress to animal test)
|
June 2014 |
